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Calciseptine

Calciseptine is a natural polypeptide toxin found in the venom of the black mamba snake (Dendroaspis p. polylepis) . Calciseptine is a highly effective and selective blocker of the L-type channel of the Cav1.2 subtype, with an IC50 value of 92 nM. Calciseptine has no effect on Cav3.1, Cav2.2, Cav2.1, Cav1.1, voltage-sensitive sodium channels and potassium channels. Calciseptine exhibits negative inotropic and negative relaxant effects on mice, and does not affect heart rate or the action potential of sinoatrial node pacemaker cells. Calciseptine can be used for research on cardiovascular diseases[1].

Product Specifications

CAS Number

178805-91-9

UNSPSC

12352209

Target

Calcium Channel

Type

Peptides

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/calciseptin.html

Solubility

10 mM in DMSO

Smiles

O=C([C@@H](N)CCCNC(N)=N)N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N1[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]2[C@@H](C)O)=O)CC(N)=O)=O)CCC(O)=O)=O)C(C)C)=O)CSSC[C@H](N3)C(NCC(N[C@H](C(N4[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N5[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]6CCC(O)=O)=O)[C@@H](C)O)=O)CCC(N)=O)=O)CC7=CC=C(O)C=C7)=O)CCC5)=O)CC8=CNC9=CC=CC=C89)=O)CCSC)=O)C)=O)[C@@H](C)O)=O)CCC4)=O)CSSC[C@H](NC6=O)C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H]%10CCCNC(N)=N)=O)CC(O)=O)=O)=O)CCCCN)=O)CSSC[C@H](NC%10=O)C(N[C@H](C(N[C@H](C(O)=O)CCCCN)=O)CC(N)=O)=O)=O)=O)=O)=O)[C@@H](C)O)=O)CCCCN)=O)[C@@H](C)O)=O)C)=O)CCCNC(N)=N)=O)CCC1)=O)CC(C)C)=O)CO)=O)C)=O)CCCCN)=O)CC%11=CNC=N%11)=O)[C@H](CC)C)=O)CC%12=CC=C(O)C=C%12)=O)CSSC[C@H](NC2=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC3=O)=O)CCCNC(N)=N)=O)CCC(O)=O)=O)CO)=O)[C@H](CC)C)=O)CC%13=CC=C(O)C=C%13)=O)CCC(O)=O)=O)CCCNC(N)=N)=O)CCC(N)=O)=O)[C@@H](C)O)=O)CCCNC(N)=N)=O)[C@H](CC)C)=O)CC%14=CC=CC=C%14)=O)CCSC)=O)CCCCN)=O)CC%15=CC=C(O)C=C%15)=O)=O)[C@H](CC)C

Molecular Formula

C299H468N90O87S10

Molecular Weight

7036.12

References & Citations

[1]Mesirca P, et al. Selective blockade of Cav1.2 (α1C) versus Cav1.3 (α1D) L-type calcium channels by the black mamba toxin calciseptine. Nat Commun. 2024 Jan 2;15 (1) :54.

Shipping Conditions

Room temperature

Scientific Category

Peptides

Clinical Information

No Development Reported

Isoform

L-type calcium channel

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