N-Methylcytisine

N-Methylcytisine (Caulophylline), a tricyclic quinolizidine alkaloid, exerts hypoglycaemic, analgesic and anti-inflammatory activities. N-methylcytisine is a selective ligand of nicotinic receptors of acetylcholine in the central nervous system and has a high affinity (Kd = 50 nM) to nicotinic acetylcholine receptors (nAChR) from squid optical ganglia[1][2].

Product Specifications

CAS Number

[486-86-2]

Product Name Alternative

Caulophylline

UNSPSC

12352005

Hazard Statement

H302+H312+H332

Target

NAChR

Type

Natural Products

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/n-methylcytisine.html

Concentration

10mM

Purity

99.81

Solubility

DMSO : 120 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)

Smiles

O=C1C=CC=C2N1C[C@]3([H])CN(C)C[C@@]2([H])C3

Molecular Formula

C12H16N2O

Molecular Weight

204.27

Precautions

H302+H312+H332

References & Citations

[1]Jiao YF, et al. N-Methylcytisine Ameliorates Dextran-Sulfate-Sodium-Induced Colitis in Mice by Inhibiting the Inflammatory Response. Molecules. 2018 Feb 25;23 (3) . pii: E510.|[2]Pliashkevich IuG, et al. [N-methylcytisine--a selective ligand of nicotinic receptors of acetylcholine in the CNS]. Biull Eksp Biol Med. 1987 Dec;104 (12) :690-2.