Sulfo DBCO-PEG4-Maleimide (TEA)

Sulfo DBCO-PEG4-Maleimide TEA is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Sulfo DBCO-PEG4-Maleimide (TEA) is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

Product Specifications

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

PROTAC Linkers

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/sulfo-dbco-peg4-maleimide-tea.html

Purity

95.0

Solubility

DMSO : ≥ 100 mg/mL

Smiles

O=C1C=CC(N1CCC(NCCOCCOCCOCCOCCC(NCC(S(=O)(O)=O)C(NCCC(N2C3=C(C#CC4=C(C2)C=CC=C4)C=CC=C3)=O)=O)=O)=O)=O.CCN(CC)CC

Molecular Formula

C45H62N6O13S

Molecular Weight

927.07

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562