NRX-252262
NRX-252262 is a potent enhancer of the interaction between β-Catenin, and its cognate E3 ligase, SCFβ-TrCP, induces mutant β-catenin degradation, with an EC50 of 3.8 nM[1].
Product Specifications
CAS Number
[2438637-61-5]
UNSPSC
12352005
Target
E1/E2/E3 Enzyme; Molecular Glues; β-catenin
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; PROTAC; Stem Cell/Wnt
Applications
Neuroscience-Neuromodulation
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/NRX-252262.html
Purity
99.57
Solubility
DMSO : 8.33 mg/mL (ultrasonic)
Smiles
O=C1C(C(N2CC(C=C(OC)C(OC)=C3)=C3C2)=O)=C(SC4=C(Cl)C=CC=C4Cl)C=C(C(F)(F)F)N1
Molecular Formula
C23H17Cl2F3N2O4S
Molecular Weight
545.36
References & Citations
[1]Kyle R. Simonetta, et al. Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction. Nature Communications. 2019 March.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
More Discoveries
Explore Other Products
Browse additional items from our catalog
MBS6321202-01 0.1 mL
MLPH, CT (MLPH, SLAC2A, Melanophilin, Exophilin-3, Slp homolog lacking C2 domains a, Synaptotagmin-like protein 2a) (MaxLight 490)
Request Quote
View Details 
MBS6321202-02 5x 0.1 mL
MLPH, CT (MLPH, SLAC2A, Melanophilin, Exophilin-3, Slp homolog lacking C2 domains a, Synaptotagmin-like protein 2a) (MaxLight 490)
Request Quote
View Details 
MBS7149504 Inquire
Rabbit anti-Arabidopsis thaliana (Mouse-ear cress) LCR36 Polyclonal Antibody
Request Quote
View Details SPN-B52H9-50ug 50 µg
Bat coronavirus BM48-31/BGR/2008 Spike Trimer Protein (R672A, KV972-973PP), His Tag
Request Quote
View Details