NRX-252262
NRX-252262 is a potent enhancer of the interaction between β-Catenin, and its cognate E3 ligase, SCFβ-TrCP, induces mutant β-catenin degradation, with an EC50 of 3.8 nM[1].
Product Specifications
CAS Number
[2438637-61-5]
UNSPSC
12352005
Target
E1/E2/E3 Enzyme; Molecular Glues; β-catenin
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; PROTAC; Stem Cell/Wnt
Applications
Neuroscience-Neuromodulation
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/NRX-252262.html
Purity
99.57
Solubility
DMSO : 8.33 mg/mL (ultrasonic)
Smiles
O=C1C(C(N2CC(C=C(OC)C(OC)=C3)=C3C2)=O)=C(SC4=C(Cl)C=CC=C4Cl)C=C(C(F)(F)F)N1
Molecular Formula
C23H17Cl2F3N2O4S
Molecular Weight
545.36
References & Citations
[1]Kyle R. Simonetta, et al. Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction. Nature Communications. 2019 March.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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