NRX-252262

NRX-252262 is a potent enhancer of the interaction between β-Catenin, and its cognate E3 ligase, SCFβ-TrCP, induces mutant β-catenin degradation, with an EC50 of 3.8 nM[1].

Product Specifications

CAS Number

[2438637-61-5]

UNSPSC

12352005

Target

E1/E2/E3 Enzyme; Molecular Glues; β-catenin

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease; PROTAC; Stem Cell/Wnt

Applications

Neuroscience-Neuromodulation

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/NRX-252262.html

Purity

99.57

Solubility

DMSO : 8.33 mg/mL (ultrasonic)

Smiles

O=C1C(C(N2CC(C=C(OC)C(OC)=C3)=C3C2)=O)=C(SC4=C(Cl)C=CC=C4Cl)C=C(C(F)(F)F)N1

Molecular Formula

C23H17Cl2F3N2O4S

Molecular Weight

545.36

References & Citations

[1]Kyle R. Simonetta, et al. Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction. Nature Communications. 2019 March.