E3 ligase Ligand 42
E3 ligase Ligand 42 is an E3 ubiquitin ligase ligand. E3 ligase Ligand 42 can be connected to the target protein ligand through a linker and can be used to synthesize PROTAC AR Degrader-6 (HY-156751) . PROTAC can induce ubiquitination degradation of cancer-promoting proteins[1].
Product Specifications
CAS Number
[2753651-18-0]
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Ligands for E3 Ligase
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/e3-ligase-ligand-42.html
Smiles
O=C(C(N(N=CC1=C2C=CC(F)=C1)C2=O)CC3)NC3=O
Molecular Formula
C13H10FN3O3
Molecular Weight
275.24
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Hongfu Lu, et al. Phthalazinone compound, and preparation method therefor and medical use thereof. WO2021249534A1. 2021-06-11
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cereblon
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