Zinc Pyrithione

Zinc Pyrithione is an antifungal and antibacterial agent disrupting membrane transport by blocking the proton pump[1]. Zinc Pyrithione is also a copper ionophore that delivers copper into cells and is a useful tool for studying cuproptosis[2].

Product Specifications

CAS Number

[13463-41-7]

UNSPSC

12352211

Hazard Statement

H301+H331, H318, H410

Target

Bacterial; Cuproptosis; Fungal; Proton Pump

Type

Reference compound

Related Pathways

Anti-infection; Apoptosis; Membrane Transporter/Ion Channel

Applications

COVID-19-anti-virus

Field of Research

Infection; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/zinc-pyrithione.html

Purity

98.35

Solubility

DMSO : 33.33 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL

Smiles

N12[O-][Zn+2]3([S]=C1C=CC=C2)[O-]N(C=CC=C4)C4=[S]3

Molecular Formula

C10H8N2O2S2Zn

Molecular Weight

317.69

Precautions

H301+H331, H318, H410

References & Citations

[1]Ermolayeva, E. and D. Sanders, Mechanism of pyrithione-induced membrane depolarization in Neurospora crassa. Appl Environ Microbiol, 1995. 61 (9) : p. 3385-90.|[2]Peter Tsvetkov, et al. Copper induces cell death by targeting lipoylated TCA cycle proteins. Science. 2022 Mar 18;375 (6586) :1254-1261.