Tepotinib (hydrochloride)
Product Specifications
UNSPSC Description
Tepotinib (EMD-1214063) hydrochloride is an orally active and highly selective, reversible, ATP-competitive c-Met inhibitor with an IC50 of 3 nM, >200-fold selective for c-Met than IRAK4, TrkA, Axl, IRAK1, and Mer. Tepotinib hydrochloride inhibits c-Met phosphorylation and induces autophagy. Tepotinib hydrochloride has antitumor effects[1][2][3].
Target Antigen
Autophagy; c-Met/HGFR
Type
Reference compound
Related Pathways
Autophagy;Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tepotinib-hydrochloride.html
Solubility
10 mM in DMSO
Smiles
N#CC1=CC=CC(C(C=CC2=O)=NN2CC3=CC=CC(C4=NC=C(C=N4)OCC5CCN(CC5)C)=C3)=C1.[H]Cl.[x]
Molecular Weight
492.57 (free base)
References & Citations
[1]Bladt F, et al. EMD 1214063 and EMD 1204831 constitute a new class of potent and highly selective c-Met inhibitors. Clin Cancer Res, 2013, 19(11), 2941-2951.|[2]A. Naing, et al. IS4-1 - A Phase I Dose-Escalation Study of emd 1214063, an Oral Selective CMET Inhibitor, in Patients with Advanced Solid Tumors. Annals of Oncology. Volume 23, Supplement 11, October 2012, Page xi21.|[3]Zhan N, et al. The Effect of Selective c-MET Inhibitor on Hepatocellular Carcinoma in the MET-Active, β-Catenin-Mutated Mouse Model. Gene Expr. 2018 May 18;18(2):135-147.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-14721A/Tepotinib-hydrochloride-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-14721A/
Clinical Information
Launched
CAS Number
1103508-80-0
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
abx037195-01 100 µg
Phosphoinositide-3-Kinase Catalytic Beta Polypeptide (PIK3CB) Antibody
Ask
View Details 
abx037195-02 1 mg
Phosphoinositide-3-Kinase Catalytic Beta Polypeptide (PIK3CB) Antibody
Ask
View Details