VTP-27999 (TFA)

VTP-27999 TFA is an alkyl amine Renin inhibitor; VTP-27999 TFA is useful for Hypertension and End-Organ Diseases.

Product Specifications

CAS Number

[1013937-63-7]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Renin

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/vtp-27999-2,2,2-trifluoroacetate.html

Purity

97.00

Solubility

Ethanol : 2.4 mg/mL (ultrasonic) |H2O : 10 mg/mL (ultrasonic)

Smiles

O=C(O)C(F)(F)F.COC(NCCO[C@@H](C1=CC(Cl)=CC=C1)[C@@]2([H])CN(CCC2)C(NC[C@@H](NC)C[C@H]3CCCOC3)=O)=O

Molecular Formula

C28H42ClF3N4O7

Molecular Weight

639.10

Precautions

H302, H315, H319, H335

References & Citations

[1]New renin inhibitor VTP-27999 alters renin immunoreactivity and does not unfold prorenin. Hypertension. 2013 May;61 (5) :1075-1082.|[2]Lanqi Jia? et al. Discovery of VTP-27999, an Alkyl Amine Renin Inhibitor with Potential for Clinical Utility ACS Med. Chem. Lett., 2011, 2 (10), pp 747-751|[3]Ishchenko A, et al. Structure-based design technology contour and its application to the design of Renin inhibitors.J Chem Inf Model. 2012 Aug 27;52 (8) :2089-97. Epub 2012 Jul 25.