Insulin-like Growth Factor-Binding Protein 3 (Human)

<strong>Insulin-like Growth Factor-Binding Protein 3 (Human)</strong>_x000D_ <strong>Catalog number:</strong> B2010280_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Volume/Weight:</strong> 10 ug_x000D_ <strong>pH:</strong> 7.4 upon reconstitution_x000D_ <strong>Supplied as:</strong> Lyophilized Powder_x000D_ <strong>Appearance:</strong> Powder_x000D_ <strong>Applications:</strong> highly pure Insulin-like Growth Factor-Binding Protein 3 (Human) expressed in E. coli. This protein acts as as a protein that prolongs the half-life of the insulin-like growth factors and inhibits the interaction of IGFs with their cell surface receptors._x000D_ <strong>Storage:</strong> -20C_x000D_ <strong>Keywords:</strong> rHuIGF-BP3; IBP-3; IGF-binding protein 3; IGFBP-3_x000D_ <strong>Grade:</strong> Biotechnology grade. All components are highly pure (minimum 95%). All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Ranke MB. Insulin-like growth factor binding-protein-3 (IGFBP-3). Best Pract_x000D_ Res Clin Endocrinol Metab. 2015 Oct;29(5):701-11._x000D_ _x000D_ 2: Price D, Muterspaugh R, Clegg B, Williams A, Stephens A, Guthrie J, Heyl D,_x000D_ Evans HG. IGFBP-3 Blocks Hyaluronan-CD44 Signaling, Leading to Increased_x000D_ Acetylcholinesterase Levels in A549 Cell Media and Apoptosis in a p53-Dependent_x000D_ Manner. Sci Rep. 2020 Mar 19;10(1):5083._x000D_ _x000D_ 3: Scully T, Scott CD, Firth SM, Sedger LM, Pintar JE, Twigg SM, Baxter RC._x000D_ Enhancement of mammary tumour growth by IGFBP-3 involves impaired T cell_x000D_ accumulation. Endocr Relat Cancer. 2018 Feb;25(2):111-122._x000D_ _x000D_ 4: Johnson MA, Firth SM. IGFBP-3: a cell fate pivot in cancer and disease._x000D_ Growth Horm IGF Res. 2014 Oct;24(5):164-73._x000D_ _x000D_ 5: Tan VY, Biernacka KM, Dudding T, Bonilla C, Gilbert R, Kaplan RC, Qibin Q,_x000D_ Teumer A, Martin RM, Perks CM, Timpson NJ, Holly JMP; PRACTICAL consortium._x000D_ Reassessing the Association between Circulating Vitamin D and IGFBP-3:_x000D_ Observational and Mendelian Randomization Estimates from Independent Sources._x000D_ Cancer Epidemiol Biomarkers Prev. 2018 Dec;27(12):1462-1471._x000D_ _x000D_ 6: Zhang Q, Jiang Y, Steinle JJ. IGFBP-3 reduces eNOS and PKCzeta_x000D_ phosphorylation, leading to lowered VEGF levels. Mol Vis. 2015 May 22;21:604-11._x000D_ _x000D_ 7: Agostini-Dreyer A, Jetzt AE, Stires H, Cohick WS. Endogenous IGFBP-3 Mediates_x000D_ Intrinsic Apoptosis Through Modulation of Nur77 Phosphorylation and Nuclear_x000D_ Export. Endocrinology. 2015 Nov;156(11):4141-51._x000D_ _x000D_ 8: Alkharobi H, Alhodhodi A, Hawsawi Y, Alkafaji H, Devine D, El-Gendy R,_x000D_ Beattie J. IGFBP-2 and -3 co-ordinately regulate IGF1 induced matrix_x000D_ mineralisation of differentiating human dental pulp cells. Stem Cell Res. 2016_x000D_ Nov;17(3):517-522._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/26333724/">9: Nguyen KH, Mishra S, Nyomba BL. In vitro differentiation of mouse brown_x000D_ preadipocytes is enhanced by IGFBP-3 expression and reduced by IGFBP-3_x000D_ silencing. Obesity (Silver Spring). 2015 Oct;23(10):2083-92. </a>_x000D_ _x000D_ <strong>Products Related to Insulin-like Growth Factor-Binding Protein 3 (Human) </strong> <a href="https://moleculardepot.com/product-category/Proteins/">: Proteins</a>