Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Anti-Hu CD354 Purified

CD354 (TREM-1), a cell surface glycoprotein expressed mainly on monocytes, macrophages, and neutrophils, but also on e.g. endothelial cells or bronchial epithelium, plays an important role in innate immune responses. Upon triggering by its ligands (mainly bacterial and fungal components, but also some viruses, such as Marburg or Ebola virus), it initiates signaling cascades leading to release of pro-inflammatory cytokines and chemokines. CD354 is strongly present in infectious inflammatory lesions (e.g. in folliculitis or impetigo), but not so much in non-infectious inflammatory lesions, (e.g. vasculitis or psoriasis) . However, under certain conditions neutrophils can upregulate CD354 also under non-infectious inflammatory conditions, e.g. in rheumatoid arthritis. Soluble CD354 (sTREM-1) is an important biomarker for identification of septic patients, as well as for prediction of their survival.

Product Specifications

Certification

RUO

Immunogen

Recombinant human CD354 fused with IgG

Target Antigen

CD354

Clone

6B1

Applications

WB, FC (QC tested), ELISA

Concentration

1 mg/mL

Format

Purified

Buffer

Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

References & Citations

*Kuemmel A, Alflen A, Schmidt LH, Sebastian M, Wiewrodt R, Schulze AB, Buhl R, Radsak M: Soluble triggering receptor expressed on myeloid cells 1 in lung cancer. Sci Rep. 2018 Jul 17;8 (1) :10766. , URL: https://pubmed.ncbi.nlm.nih.gov/30018308/, *Alflen A, Stadler N, Lopez PA, Teschner D, Theobald M, Heß G, Radsak MP: Idelalisib impairs TREM-1 mediated neutrophil inflammatory responses. Sci Rep. 2018 Apr 3;8 (1) :5558., URL: https://pubmed.ncbi.nlm.nih.gov/29615799/, *Prüfer S, Weber M, Sasca D, Teschner D, Wölfel C, Stein P, Stassen M, Schild H, Radsak MP: Distinct signaling cascades of TREM-1, TLR and NLR in neutrophils and monocytic cells. J Innate Immun. 2014;6 (3) :339-52. , URL: https://pubmed.ncbi.nlm.nih.gov/24281714/, *Hasibeder A, Stein P, Brandwijk R, Schild H, Radsak MP: Evaluation and validation of the detection of soluble triggering receptor expressed on myeloid cells 1 by enzyme-linked immunosorbent assay. Sci Rep. 2015 Oct 20;5:15381., URL: https://pubmed.ncbi.nlm.nih.gov/26480887/

Storage Conditions

Store at 2-8°C. Do not freeze.

Specificity

The mouse monoclonal antibody 6B1 (also known as 6B1.1G12) recognizes an extracellular epitope of human CD354 (TREM-1), a transmembrane glycoprotein, serving as an important innate immunity receptor.

Applications Notes

Flow cytometry: Recommended dilution: 1-4 µg/ml.

Species

Human

CAS Number

9007-83-4

Isotype

Mouse IgG1

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

KHK-IN-2
M26269-01 1 g

KHK-IN-2

Ask
View Details
KHK-IN-2
M26269-02 200 mg

KHK-IN-2

Ask
View Details
KHK-IN-2
M26269-03 500 mg

KHK-IN-2

Ask
View Details
KHK-IN-2
M26269-04 5 mg

KHK-IN-2

Ask
View Details
KHK-IN-2
M26269-05 10 mg

KHK-IN-2

Ask
View Details
KHK-IN-2
M26269-06 25 mg

KHK-IN-2

Ask
View Details