TQL-1055

Product Specifications

CAS Number

[2095876-40-5]

UNSPSC Description

TQL-1055 is a semi-synthetic analog of the saponin adjuvant QS-21 (HY-101092) and can be used as a prophylactic vaccine adjuvant. TQL-1055 exhibits robust adjuvant activity for influenza antigens. TQL-1055 combined with the acellular pertussis vaccine (aP) shows good tolerance and enhances the antibody response to pertussis toxin (PT) in mice and rabbits. TQL-1055 is promising for research of chronic hepatitis B[1][2].

Target Antigen

Influenza Virus

Type

Reference compound

Related Pathways

Anti-infection

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/tql-1055.html

Smiles

O[C@H]([C@@H]([C@H]([C@@H](O1)C)O[C@H]2[C@@H]([C@H]([C@@H](CO2)O)O)O)O)[C@@H]1O[C@H]([C@H]([C@H]([C@H](O3)CO)NC(CCCCCCCCCCC(O)=O)=O)O)[C@@H]3OC([C@]45[C@](CC(C)(CC5)C)([H])C6=CC[C@@]([C@@]7([C@@]([C@@](C)([C@H](CC7)O)C=O)([H])CC8)C)([H])[C@]8(C)[C@@]6(C[C@H]4O)C)=O

Molecular Weight

1138.38

References & Citations

[1]Duan H, et al. Long trimer-immunization interval and appropriate adjuvant reduce immune responses to the soluble HIV-1-envelope trimer base. iScience. 2024 Jan 11;27(2):108877.|[2]Buzz C, et al. 1238. The Novel Semisynthetic Saponin Adjuvant TQL1055 Enhances the Antibody Response to Pertussis Vaccine with an Improved Tolerability Profile over QS-21[C]//Open Forum Infectious Diseases. Oxford University Press, 2020, 7(Suppl 1): S638.