AC-186

AC-186 is a selective non-steroidal estrogen receptor β (ERβ) agonist with EC50s of 6 nM and 5000 nM for ERβ and ERα, respectively. AC-186 shows gender selective neuroprotective effects in a male rat model of Parkinson's disease[1].

Product Specifications

CAS Number

[1421854-16-1]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Estrogen Receptor/ERR

Type

Reference compound

Related Pathways

Vitamin D Related/Nuclear Receptor

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ac-186.html

Purity

99.61

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

FC1=C(C=CC=C1)C2(C3=CC=C(O)C=C3)CCC(F)(F)CC2

Molecular Formula

C18H17F3O

Molecular Weight

306.32

Precautions

H302, H315, H319, H335

References & Citations

[1]McFarland K, et al. AC-186, a selective nonsteroidal estrogen receptor β agonist, shows gender specific neuroprotection in a Parkinson's disease rat model. ACS Chem Neurosci. 2013 Sep 18;4 (9) :1249-55.|[2]Jian-Nong Ma, et al. Estrogen Receptor Beta Selective Agonists as Agents to Treat Chemotherapeutic-Induced Neuropathic Pain. ACS Chem Neurosci. 2016 Sep 21;7 (9) :1180-7.