P-MPPF (dihydrochloride)
P-MPPF dihydrochloride is a selective 5-HT antagonist that dose-dependently antagonizes the reduction of phosphorylated Erk1/2 levels in the hippocampus induced by 8-OH-DPAT in rats. p-MPPF dihydrochloride can be used for neurological disease research[1].
Product Specifications
CAS Number
223699-41-0
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
5-HT Receptor; PERK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; GPCR/G Protein; Neuronal Signaling
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/p-mppf-dihydrochloride.html
Smiles
O=C(N(CCN1CCN(C2=CC=CC=C2OC)CC1)C3=NC=CC=C3)C4=CC=C(F)C=C4.Cl.Cl
Molecular Formula
C25H29Cl2FN4O2
Molecular Weight
507.43
Precautions
P261-P280-P302+P352
References & Citations
[1]Chen J, et al. 5-HT1A receptor-mediated regulation of mitogen-activated protein kinase phosphorylation in rat brain. Eur J Pharmacol. 2002 Oct 4;452 (2) :155-62.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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