P-MPPF (dihydrochloride)

P-MPPF dihydrochloride is a selective 5-HT antagonist that dose-dependently antagonizes the reduction of phosphorylated Erk1/2 levels in the hippocampus induced by 8-OH-DPAT (HY-112061) in rats. p-MPPF dihydrochloride can be used for neurological disease research[1].

Product Specifications

CAS Number

[223699-41-0]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

5-HT Receptor; PERK

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; GPCR/G Protein; Neuronal Signaling

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/p-mppf-dihydrochloride.html

Smiles

O=C(N(CCN1CCN(C2=CC=CC=C2OC)CC1)C3=NC=CC=C3)C4=CC=C(F)C=C4.Cl.Cl

Molecular Formula

C25H29Cl2FN4O2

Molecular Weight

507.43

Precautions

P261-P280-P302+P352

References & Citations

[1]Chen J, et al. 5-HT1A receptor-mediated regulation of mitogen-activated protein kinase phosphorylation in rat brain. Eur J Pharmacol. 2002 Oct 4;452 (2) :155-62.