Human Osteoprotegerin (Recombinant)

<strong>Osteoprotegerin (Human, Recombinant)</strong>_x000D_ <strong>Catalog number:</strong> B2010321_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Volume/Weight:</strong> 10 ug_x000D_ <strong>pH:</strong> 7.4 upon reconstitution_x000D_ <strong>Supplied as:</strong> Lyophilized Powder_x000D_ <strong>Appearance:</strong> Powder_x000D_ <strong>Applications:</strong> highly pure Osteoprotegerin (Human, Recombinant) expressed in CHO. This protein acts as a decoy receptor for the Receptor Activator of Nuclear Factor-kB ligand (RANKL) and is a member of the TNF receptor superfamily._x000D_ <strong>Storage:</strong> -20C_x000D_ <strong>Keywords:</strong> rHuOPG; Tumor necrosis factor receptor superfamily member 11B; TNFRSF11B; OCIF_x000D_ <strong>Grade:</strong> Biotechnology grade. All components are highly pure (minimum 95%). All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Boyce BF, Xing L. Biology of RANK, RANKL, and osteoprotegerin. Arthritis Res_x000D_ Ther. 2007;9 Suppl 1(Suppl 1):S1._x000D_ _x000D_ 2: Rochette L, Meloux A, Rigal E, Zeller M, Cottin Y, Vergely C. The Role of_x000D_ Osteoprotegerin and Its Ligands in Vascular Function. Int J Mol Sci. 2019 Feb_x000D_ 6;20(3):705._x000D_ _x000D_ 3: Rochette L, Meloux A, Rigal E, Zeller M, Cottin Y, Vergely C. The role of_x000D_ osteoprotegerin in the crosstalk between vessels and bone: Its potential utility_x000D_ as a marker of cardiometabolic diseases. Pharmacol Ther. 2018 Feb;182:115-132._x000D_ _x000D_ 4: Makarović S, Makarović Z, Steiner R, Mihaljević I, Milas-Ahić J._x000D_ Osteoprotegerin and Vascular Calcification: Clinical and Prognostic Relevance._x000D_ Coll Antropol. 2015 Jun;39(2):461-8._x000D_ _x000D_ 5: Özkalaycı F, Gülmez Ö, Uğur-Altun B, Pandi-Perumal SR, Altun A. The Role of_x000D_ Osteoprotegerin as a Cardioprotective Versus Reactive Inflammatory Marker: the_x000D_ Chicken or the Egg Paradox. Balkan Med J. 2018 May 29;35(3):225-232._x000D_ _x000D_ 6: Valentini A, Cianfarani MA, Tarantino U, Di Daniele N, Bertoli A._x000D_ Osteoprotegerin as a biomarker of geriatric frailty syndrome. Aging (Albany NY)._x000D_ 2019 Jul 17;11(14):4900-4909._x000D_ _x000D_ 7: Sasso GR, Florencio-Silva R, Simões RS, Baracat MC, Soares Júnior JM, Baracat_x000D_ EC. Elevated serum osteoprotegerin levels in women: friend or foe? Rev Assoc Med_x000D_ Bras (1992). 2015 Nov-Dec;61(6):524-9._x000D_ _x000D_ 8: Weichhaus M, Chung ST, Connelly L. Osteoprotegerin in breast cancer: beyond_x000D_ bone remodeling. Mol Cancer. 2015 Jun 10;14:117. doi: 10.1186/s12943-015-0390-5._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/28077433/">9: Jia D, Zhu Q, Liu H, Zuo C, He Y, Chen G, Lu A. Osteoprotegerin Disruption_x000D_ Attenuates HySu-Induced Pulmonary Hypertension Through Integrin αvβ3/FAK/AKT_x000D_ Pathway Suppression. Circ Cardiovasc Genet. 2017 Feb;10(1):e001591. </a>_x000D_ _x000D_ <strong>Products Related to Osteoprotegerin (Human, Recombinant) </strong> <a href="https://moleculardepot.com/product-category/Proteins/">: Proteins</a>