Etidronic acid,60% in water
Etidronic acid (Etidronate) is an orally and intravenously active bisphosphonate. Etidronic acid inhibits resorption of bone, reduces arterial calcification and can be used for osteoporosis research. Etidronic acid has anticancer activity. Etidronic acid is a chelating agent and can be used to remove heavy metal in water[1][2][3][4].
Product Specifications
CAS Number
2809-21-4
Product Name Alternative
Etidronate; HEDPA; HEDP
UNSPSC
12352211
Hazard Statement
H303, H318, H411
Target
Apoptosis
Type
Reference compound
Related Pathways
Apoptosis
Field of Research
Cancer; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/Etidronic-acid.html
Purity
98.0
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)
Smiles
OC(P(O)(O)=O)(P(O)(O)=O)C
Molecular Formula
C2H8O7P2
Molecular Weight
206.03
Precautions
H303, H318, H411
References & Citations
[1]Dunn CJ, et al. Etidronic acid. A review of its pharmacological properties and therapeutic efficacy in resorptive bone disease. Drugs Aging. 1994 Dec;5 (6) :446-74. |[2]Ariyoshi T, et al. Effect of etidronic acid on arterial calcification in dialysis patients. Clin Drug Investig. 2006;26 (4) :215-22. |[3]Zhou Y, et al. Cytotoxicity of etidronic acid to human breast cancer cells. Ethn Dis. 2008 Spring;18 (2 Suppl 2) :S2-87-92. |[4]Zhu S, et al. In-Depth Study of Heavy Metal Removal by an Etidronic Acid-Functionalized Layered Double Hydroxide. ACS Appl Mater Interfaces. 2022 Feb 9;14 (5) :7450-7463. |[5]Kameda T, et al. Estrogen inhibits bone resorption by directly inducing apoptosis of the bone-resorbing osteoclasts. J Exp Med. 1997 Aug 18;186 (4) :489-95.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
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