Etidronic acid,60% in water

Etidronic acid (Etidronate) is an orally and intravenously active bisphosphonate. Etidronic acid inhibits resorption of bone, reduces arterial calcification and can be used for osteoporosis research. Etidronic acid has anticancer activity. Etidronic acid is a chelating agent and can be used to remove heavy metal in water[1][2][3][4].

Product Specifications

CAS Number

[2809-21-4]

Product Name Alternative

Etidronate; HEDPA; HEDP

UNSPSC

12352211

Hazard Statement

H303, H318, H411

Target

Apoptosis

Type

Reference compound

Related Pathways

Apoptosis

Field of Research

Cancer; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/Etidronic-acid.html

Purity

98.0

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)

Smiles

OC(P(O)(O)=O)(P(O)(O)=O)C

Molecular Formula

C2H8O7P2

Molecular Weight

206.03

Precautions

H303, H318, H411

References & Citations

[1]Dunn CJ, et al. Etidronic acid. A review of its pharmacological properties and therapeutic efficacy in resorptive bone disease. Drugs Aging. 1994 Dec;5 (6) :446-74. |[2]Ariyoshi T, et al. Effect of etidronic acid on arterial calcification in dialysis patients. Clin Drug Investig. 2006;26 (4) :215-22. |[3]Zhou Y, et al. Cytotoxicity of etidronic acid to human breast cancer cells. Ethn Dis. 2008 Spring;18 (2 Suppl 2) :S2-87-92. |[4]Zhu S, et al. In-Depth Study of Heavy Metal Removal by an Etidronic Acid-Functionalized Layered Double Hydroxide. ACS Appl Mater Interfaces. 2022 Feb 9;14 (5) :7450-7463. |[5]Kameda T, et al. Estrogen inhibits bone resorption by directly inducing apoptosis of the bone-resorbing osteoclasts. J Exp Med. 1997 Aug 18;186 (4) :489-95.