ALW-II-41-27

ALW-II-41-27 is a Eph family tyrosine kinase inhibitor with an IC50 of 11 nM for Eph2.

Product Specifications

CAS Number

[1186206-79-0]

Product Name Alternative

Eph receptor tyrosine kinase inhibitor

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Ephrin Receptor

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ALW-II-41-27.html

Purity

99.70

Solubility

DMSO : ≥ 47 mg/mL

Smiles

CC1=C(NC(C2=CC(C3=CC=CS3)=CN=C2)=O)C=C(C(NC4=CC=C(CN5CCN(CC)CC5)C(C(F)(F)F)=C4)=O)C=C1

Molecular Formula

C32H32F3N5O2S

Molecular Weight

607.69

Precautions

H302, H315, H319, H335

References & Citations

[1]Choi, et al. Discovery and structural analysis of Eph receptor tyrosine kinase inhibitors. Bioorganic & Medicinal Chemistry Letters (2009), 19 (15), 4467-4470.|[2]Song W, et al. Targeting EphA2 impairs cell cycle progression and growth of basal-like/triple-negative breast cancers. Oncogene. 2017 Jun 5.