ALW-II-41-27
ALW-II-41-27 is a Eph family tyrosine kinase inhibitor with an IC50 of 11 nM for Eph2.
Product Specifications
CAS Number
[1186206-79-0]
Product Name Alternative
Eph receptor tyrosine kinase inhibitor
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Ephrin Receptor
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ALW-II-41-27.html
Purity
99.70
Solubility
DMSO : ≥ 47 mg/mL
Smiles
CC1=C(NC(C2=CC(C3=CC=CS3)=CN=C2)=O)C=C(C(NC4=CC=C(CN5CCN(CC)CC5)C(C(F)(F)F)=C4)=O)C=C1
Molecular Formula
C32H32F3N5O2S
Molecular Weight
607.69
Precautions
H302, H315, H319, H335
References & Citations
[1]Choi, et al. Discovery and structural analysis of Eph receptor tyrosine kinase inhibitors. Bioorganic & Medicinal Chemistry Letters (2009), 19 (15), 4467-4470.|[2]Song W, et al. Targeting EphA2 impairs cell cycle progression and growth of basal-like/triple-negative breast cancers. Oncogene. 2017 Jun 5.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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