Mollugin
Mollugin is an orally active and potent NF-κB inhibitor. Mollugin induces S-phase arrest of HepG2 cells, and increased intracellular reactive oxygen species (ROS) levels. Mollugin induces DNA damage in HepG2 cells, as well as an increase in the expression of p-H2AX. Mollugin shows anti-cancer effect by inhibiting TNF-α-induced NF-κB activation. Mollugin enhances the osteogenic action of BMP-2 (bone morphogenetic protein 2) via the p38-Smad signaling pathway[1][2][3].
Product Specifications
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; c-Myc; JAK; NF-κB; Reactive Oxygen Species (ROS) ; VEGFR
Type
Natural Products
Related Pathways
Apoptosis; Epigenetics; Immunology/Inflammation; JAK/STAT Signaling; Metabolic Enzyme/Protease; NF-κB; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mollugin.html
Purity
99.79
Solubility
DMSO : 33.33 mg/mL (ultrasonic)
Smiles
O=C(C1=C(C=CC(C)(C)O2)C2=C3C=CC=CC3=C1O)OC
Molecular Formula
C17H16O4
Molecular Weight
284.31
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-N0316/Mollugin-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-N0316/Mollugin-SDS-MedChemExpress.pdf
Scientific Category
Natural Products
Clinical Information
No Development Reported
CAS Number
[55481-88-4]
Available Sizes
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