Nortadalafil

Nortadalafil (Demethyl Tadalafil), a tadalafil (HY-90009A) analogue detected in health foods, is a highly selective PDE5 inhibitor. Nortadalafil is used in the research of erectile dysfunction (ED) . Nortadalafil can be formed by closing the diketopiperazine ring in high yield. Nortadalafil is promising for research of pulmonary arterial hypertension[1][2][3][4][5][6].

Product Specifications

CAS Number

[171596-36-4]

Product Name Alternative

Demethyl Tadalafil

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Phosphodiesterase (PDE)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/Nortadalafil.html

Purity

99.71

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C1NCC(N([C@@H]1C2)[C@H](C3=CC=C(OCO4)C4=C3)C5=C2C6=C(N5)C=CC=C6)=O

Molecular Formula

C21H17N3O4

Molecular Weight

375.38

Precautions

H302, H315, H319, H335

References & Citations

[1]Daugan, et al. The discovery of tadalafil: a novel and highly selective PDE5 inhibitor. 2: 2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione analogue. Journal of Medicinal Chemistry (2003), 46 (21), 4533-4542.|[2]Porst H, et al. Chronic PDE-5 inhibition in patients with erectile dysfunction - a treatment approach using tadalafil once-daily. Expert Opin Pharmacother. 2012 Jul;13 (10) :1481-94.|[3]Frey MK, Lang I. Tadalafil for the treatment of pulmonary arterial hypertension. Expert Opin Pharmacother. 2012 Apr;13 (5) :747-55.|[4]HUANG ZHi, et al. Discovery of Nortadalafil in Health Foods[J]. Chinese Pharmaceutical Journal, 2015, 50 (4) : 371-374.|[5]Fukiwake T, et al. [The Configuration of Tadalafil and Tadalafil Analogues Found in Dietary Supplements][J]. Shokuhin Eiseigaku Zasshi. 2021;62 (2) :65-72. |[6]Beghyn T, et al. PDE5 inhibitors: An original access to novel potent arylated analogues of tadalafil. Bioorg Med Chem Lett[J]. 2007 Feb 1;17 (3) :789-92.