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CD117/c-kit, Rat (HEK293, Fc)

CD117, also known as tyrosine-protein kinase KIT or mast/stem cell growth factor receptor (SCFR), is a cytokine receptor that is expressed on the surface of hematopoietic stem cells and other cell types. CD117 signaling pathway plays an important role in cell survival, proliferation and differentiation. CD117 is a proto-oncogene associated with tumor development. CD117/c-kit Protein, Rat (HEK293, Fc) is the recombinant rat-derived CD117/c-kit protein, expressed by HEK293 , with C-hFc labeled tag.

Product Specifications

Product Name Alternative

CD117/c-kit Protein, Rat (HEK293, Fc), Rat, HEK293

UNSPSC

12352202

Type

Recombinant Proteins

Assay Protocol

https://www.medchemexpress.com/cytokines/cd117-c-kit-protein-rat-hek293-fc.html

Molecular Formula

64030 (Gene_ID) Q63116 (M1-T522) (Accession)

Molecular Weight

Approximately 114-119 kDa, based on SDS-PAGE under reducing conditions.

References & Citations

[1]Andre C, et al. Sequence analysis of two genomic regions containing the KIT and the FMS receptor tyrosine kinase genes. Genomics. 1997 Jan 15;39 (2) :216-26.|[2]Edling CE, et al. c-Kit--a hematopoietic cell essential receptor tyrosine kinase. Int J Biochem Cell Biol. 2007;39 (11) :1995-8.|[3]Blume-Jensen P, et al. Activation of the human c-kit product by ligand-induced dimerization mediates circular actin reorganization and chemotaxis. EMBO J. 1991 Dec;10 (13) :4121-8.|[4]Miettinen M, et al. KIT (CD117) : a review on expression in normal and neoplastic tissues, and mutations and their clinicopathologic correlation. Appl Immunohistochem Mol Morphol. 2005 Sep;13 (3) :205-20.

Shipping Conditions

Dry ice.

Scientific Category

Recombinant Proteins

Frequently Asked Questions

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