Acetyl-Calpastatin(184-210)(human) (TFA)
Product Specifications
UNSPSC Description
Acetyl-Calpastatin(184-210)(human) TFA is a potent, selective and reversible calpain inhibitor with Ki values of 0.2 nM and 6 μM for µ-calpain and cathepsin L, respectively[1][2].
Target Antigen
Proteasome
Type
Peptides
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/acetyl-calpastatin-184-210-human-tfa.html
Solubility
H2O
Smiles
OC(C(F)(F)F)=O.O=C(N1[C@@H](CCC1)C(N[C@@H](CCCCN)C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](C)C(N)=O)=O)=O)=O)=O)=O)CC2=CC=C(C=C2)O)=O)=O)[C@H]3N(CCC3)C([C@H]([C@@H](C)CC)NC([C@H]([C@H](O)C)NC([C@H](C(C)C)NC([C@H](CCC(O)=O)NC([C@H](CCCNC(N)=N)NC([C@H](CCCCN)NC(CNC([C@H](CC(C)C)NC([C@H](CCC(O)=O)NC([C@H](CCC(O)=O)NC([C@H]([C@@H](C)CC)NC([C@@H](NC([C@H]([C@H](O)C)NC([C@H](CO)NC([C@H](CO)NC([C@H](CCSC)NC([C@H]4N(CCC4)C([C@@H](NC(C)=O)CC(O)=O)=O)=O)=O)=O)=O)=O)CC5=CC=C(C=C5)O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O
Molecular Weight
3291.65
References & Citations
[1]Ferdinando Fiorino, et al. A new cell-permeable calpain inhibitor. J Pept Sci. 2007 Jan;13(1):70-3.|[2]Benjamin P Davis, et al. Eosinophilic esophagitis-linked calpain 14 is an IL-13-induced protease that mediates esophageal epithelial barrier impairment. JCI Insight. 2016 Apr;1(4):e86355.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-P1081A/Acetyl-Calpastatin-184-210-human-TFA-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-P1081A/
Clinical Information
No Development Reported
Curated Selection
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