Acetyl-Calpastatin (184-210) (human) (TFA)

Acetyl-Calpastatin (184-210) (human) TFA is a potent, selective and reversible calpain inhibitor with Ki values of 0.2 nM and 6 μM for µ-calpain and cathepsin L, respectively[1][2].

Product Specifications

UNSPSC

12352209

Target

Proteasome

Type

Peptides

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/acetyl-calpastatin-184-210-human-tfa.html

Solubility

H2O

Smiles

OC(C(F)(F)F)=O.O=C(N1[C@@H](CCC1)C(N[C@@H](CCCCN)C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](C)C(N)=O)=O)=O)=O)=O)=O)CC2=CC=C(C=C2)O)=O)=O)[C@H]3N(CCC3)C([C@H]([C@@H](C)CC)NC([C@H]([C@H](O)C)NC([C@H](C(C)C)NC([C@H](CCC(O)=O)NC([C@H](CCCNC(N)=N)NC([C@H](CCCCN)NC(CNC([C@H](CC(C)C)NC([C@H](CCC(O)=O)NC([C@H](CCC(O)=O)NC([C@H]([C@@H](C)CC)NC([C@@H](NC([C@H]([C@H](O)C)NC([C@H](CO)NC([C@H](CO)NC([C@H](CCSC)NC([C@H]4N(CCC4)C([C@@H](NC(C)=O)CC(O)=O)=O)=O)=O)=O)=O)=O)CC5=CC=C(C=C5)O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O

Molecular Formula

C144H231F3N36O46S

Molecular Weight

3291.65

References & Citations

[1]Ferdinando Fiorino, et al. A new cell-permeable calpain inhibitor. J Pept Sci. 2007 Jan;13 (1) :70-3.|[2]Benjamin P Davis, et al. Eosinophilic esophagitis-linked calpain 14 is an IL-13-induced protease that mediates esophageal epithelial barrier impairment. JCI Insight. 2016 Apr;1 (4) :e86355.