N-[3- (2-Furyl) acryloyl]-Phe-Gly-Gly
Selected Variant
HY-W010991-01
Size: 10 mg
N-[3- (2-Furyl) acryloyl]-Phe-Gly-Gly (FAPGG) is a specific substrate of angiotensin converting enzyme (ACE) with a Ki of 2.546x10-4 M. It is used as a chromogenic probe for quantitative detection of ACE activity. N-[3- (2-Furyl) acryloyl]-Phe-Gly-Gly can be hydrolyzed by ACE to generate N-[3- (2-furyl) acryloyl]-Phe (FAP) and Gly-Gly, and the ACE inhibitory effect is monitored by photometry. FAPGG competitively binds to the active center of ACE and is a key tool for screening ACE inhibitors such as Captopril and Dioscorin. Its reversible mechanism of action supports hypertension research and drug development targeting the renin-angiotensin system[1].
Product Specifications
CAS Number
64967-39-1
Product Name Alternative
FAPGG
UNSPSC
12171500
Hazard Statement
H302, H315, H319, H335
Target
Angiotensin-converting Enzyme (ACE)
Type
Dye Reagents
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/n-3-2-furyl-acryloyl-phe-gly-gly.html
Purity
99.81
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(O)CNC(CNC([C@@H](NC(/C=C/C1=CC=CO1)=O)CC2=CC=CC=C2)=O)=O
Molecular Formula
C20H21N3O6
Molecular Weight
399.40
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light)
Scientific Category
Dye Reagents
Clinical Information
No Development Reported
Available Sizes
Price
Frequently Asked Questions
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