N-[3- (2-Furyl) acryloyl]-Phe-Gly-Gly

N-[3- (2-Furyl) acryloyl]-Phe-Gly-Gly (FAPGG) is a specific substrate of angiotensin converting enzyme (ACE) with a Ki of 2.546x10-4 M. It is used as a chromogenic probe for quantitative detection of ACE activity. N-[3- (2-Furyl) acryloyl]-Phe-Gly-Gly can be hydrolyzed by ACE to generate N-[3- (2-furyl) acryloyl]-Phe (FAP) and Gly-Gly, and the ACE inhibitory effect is monitored by photometry. FAPGG competitively binds to the active center of ACE and is a key tool for screening ACE inhibitors such as Captopril (HY-B0368) and Dioscorin. Its reversible mechanism of action supports hypertension research and drug development targeting the renin-angiotensin system[1].

Product Specifications

CAS Number

[64967-39-1]

Product Name Alternative

FAPGG

UNSPSC

12171500

Hazard Statement

H302, H315, H319, H335

Target

Angiotensin-converting Enzyme (ACE)

Type

Dye Reagents

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/n-3-2-furyl-acryloyl-phe-gly-gly.html

Purity

99.81

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(O)CNC(CNC([C@@H](NC(/C=C/C1=CC=CO1)=O)CC2=CC=CC=C2)=O)=O

Molecular Formula

C20H21N3O6

Molecular Weight

399.40

Precautions

H302, H315, H319, H335

References & Citations

[1]Hsu FL, et al. Both dioscorin, the tuber storage protein of yam (Dioscorea alata cv. Tainong No. 1), and its peptic hydrolysates exhibited angiotensin converting enzyme inhibitory activities. J Agric Food Chem. 2002 Oct 9;50 (21) :6109-13.