PF-06465469
Product Specifications
UNSPSC Description
PF-06465469 is a covalent inhibitor of ITK with an IC50 of 2 nM[1].
Target Antigen
Itk
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pf-06465469.html
Purity
99.48
Solubility
DMSO : 11 mg/mL (ultrasonic)
Smiles
O=C(NC1=CC=C(C(C)C)C(C)=C1)C2=CC=CC(C3=NN([C@H]4CN(C(C=C)=O)CCC4)C5=NC=NC(N)=C53)=C2
Molecular Weight
523.63
References & Citations
[1]Mamand S, et al. Comparison of interleukin-2-inducible kinase (ITK) inhibitors and potential for combination therapies for T-cell lymphoma. Sci Rep. 2018 Sep 21;8(1):14216.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-108691/PF-06465469-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-108691/PF-06465469-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1407966-77-1
Available Sizes
Curated Selection
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