(-) -Blebbistatin

(-) -Blebbistatin is a selective inhibitor of the ATPase activity of non-muscle myosin II[1][2].

Product Specifications

CAS Number

[856925-71-8]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Myosin

Type

Reference compound

Related Pathways

Cytoskeleton

Applications

COVID-19-immunoregulation

Field of Research

Cardiovascular Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/_-_-Blebbistatin.html

Purity

99.42

Solubility

DMSO : 10 mg/mL (ultrasonic)

Smiles

CC1=CC=C(N=C(N(C2=CC=CC=C2)CC3)[C@]3(O)C4=O)C4=C1

Molecular Formula

C18H16N2O2

Molecular Weight

292.34

Precautions

H302, H315, H319, H335

References & Citations

[1]Cristina Lucas‐Lopez, et al. Absolute Stereochemical Assignment and Fluorescence Tuning of the Small Molecule Tool, (–) ‐Blebbistatin.|[2]Ponsaerts R, et al. The myosin II ATPase inhibitor blebbistatin prevents thrombin-induced inhibition of intercellularcalcium wave propagation in corneal endothelial cells. Invest Ophthalmol Vis Sci. 2008 Nov;49 (11) :4816-27.