3-Isomangostin
3-Isomangostin, extracted from Garciniamangostana.L. shell, is a potent MutT homologue 1 (MTH1) inhibitor with an IC50 value of 52 nM. 3-Isomangostin would be an attractive chemical tool for the development of anticancer agents[1].
Product Specifications
CAS Number
[19275-46-8]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
DNA/RNA Synthesis
Type
Natural Products
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/3-isomangostin.html
Purity
99.14
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
C/C(C)=C\CC1=C2C(OC3=C(C(O)=C4C(OC(C)(C)CC4)=C3)C2=O)=CC(O)=C1OC
Molecular Formula
C24H26O6
Molecular Weight
410.46
Precautions
H302, H315, H319, H335
References & Citations
[1]Yokoyama T, et al. Discovery of a new class of MTH1 inhibitor by X-ray crystallographic screening. Eur J Med Chem. 2019 Apr 1;167:153-160.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Available Sizes
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