TGF-βRI inhibitor 2
TGF-βRI inhibitor 2 (compound 13) is a TGF-βRI inhibitor. TGF-βRI inhibitor 2 can be used in cancer research[1].
Product Specifications
CAS Number
[476474-11-0]
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
TGF-β Receptor
Type
Reference compound
Related Pathways
TGF-beta/Smad
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tgf-βri-inhibitor-2.html
Purity
98.32
Solubility
DMSO : 7.14 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
OC1=CC=C2C(C(C(C3=CC=CC=N3)=N4)=C5N4CCC5)=CC=NC2=C1
Molecular Formula
C20H16N4O
Molecular Weight
328.37
Precautions
H315, H319, H335
References & Citations
[1]Li HY, et al. Optimization of a dihydropyrrolopyrazole series of transforming growth factor-beta type I receptor kinase domain inhibitors: discovery of an orally bioavailable transforming growth factor-beta receptor type I inhibitor as antitumor agent. J Med Chem. 2008 Apr 10;51 (7) :2302-6.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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