TGF-βRI inhibitor 2

TGF-βRI inhibitor 2 (compound 13) is a TGF-βRI inhibitor. TGF-βRI inhibitor 2 can be used in cancer research[1].

Product Specifications

CAS Number

[476474-11-0]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

TGF-β Receptor

Type

Reference compound

Related Pathways

TGF-beta/Smad

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/tgf-βri-inhibitor-2.html

Purity

98.32

Solubility

DMSO : 7.14 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

OC1=CC=C2C(C(C(C3=CC=CC=N3)=N4)=C5N4CCC5)=CC=NC2=C1

Molecular Formula

C20H16N4O

Molecular Weight

328.37

Precautions

H315, H319, H335

References & Citations

[1]Li HY, et al. Optimization of a dihydropyrrolopyrazole series of transforming growth factor-beta type I receptor kinase domain inhibitors: discovery of an orally bioavailable transforming growth factor-beta receptor type I inhibitor as antitumor agent. J Med Chem. 2008 Apr 10;51 (7) :2302-6.