Antitumor agent-150
Antitumor agent-150 (V10), an anti-breast cancer agent, is a PROTAC-based MDM2 protein degrader (Red: Ganoderic acid A; Black: 4O-PEG linker; Blue: VHL ligand) [1].
Product Specifications
CAS Number
9007-83-4
UNSPSC
12352005
Target
Apoptosis; MDM-2/p53; PROTACs
Type
Reference compound
Related Pathways
Apoptosis; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/antitumor-agent-150.html
Solubility
10 mM in DMSO
Smiles
O=C1C[C@@]2(C)[C@]([C@@H](O)C[C@@H]2[C@H](C)CC(C[C@@H](C)C(NCCOCCOCCOCCOCCN3CC(CCCCC(N[C@@H](C(C)(C)C)C(N4C[C@H](O)C[C@H]4C(N[C@@H](C)C5=CC=C(C6=C(C)N=CS6)C=C5)=O)=O)=O)N=N3)=O)=O)(C)C7=C1[C@]8(C)[C@](C[C@@H]7O)([H])C(C)(C)C(CC8)=O
Molecular Formula
C70H106N8O14S
Molecular Weight
1315.70
References & Citations
[1]Yan Li, et al. Discovery of ganoderic acid A (GAA) PROTACs as MDM2 protein degraders for the treatment of breast cancer. Eur J Med Chem. 2024 Apr 15:270:116367.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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