Oxazosulfyl

Oxazosulfyl is a sulfyl insecticide with potent and cross-spectrum insecticidal activity. Oxazosulfyl inhibits sodium currents by binding to and stabilizing the slow-inactivated state of voltage-gated sodium channels, leading to insect paralysis. Oxazosulfyl's ability to block sodium channels is correlated with its insecticidal activity[1][2].

Product Specifications

CAS Number

[1616678-32-0]

UNSPSC

12352005

Hazard Statement

H302, H312, H315, H319, H332, H335

Target

Insecticide; Parasite; Sodium Channel

Type

Reference compound

Related Pathways

Anti-infection; Membrane Transporter/Ion Channel; Others

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/oxazosulfyl.html

Purity

99.66

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=S(C1=CC=C(OC(C2=NC=CC=C2S(=O)(CC)=O)=N3)C3=C1)(C(F)(F)F)=O

Molecular Formula

C15H11F3N2O5S2

Molecular Weight

420.38

Precautions

H302, H312, H315, H319, H332, H335

References & Citations

[1]Rosemary Lees, et al. A Testing Cascade to Identify Repurposed Insecticides for Next-Generation Vector Control Tools: Screening a Panel of Chemistries With Novel Modes of Action Against a Malaria Vector. Gates Open Res. 2019 Jul 10;3:1464.|[2]Suzuki T, et al. Oxazosulfyl, a Novel Sulfyl Insecticide, Binds to and Stabilizes the Voltage-Gated Sodium Channels in the Slow-Inactivated State. J Agric Food Chem. 2021 Apr 14;69 (14) :4048-4055.