5'-O- (4,4'-Dimethoxytrityl) -2'-deoxyuridine

5'-O- (4,4'-Dimethoxytrityl) -2'-deoxyuridine (5'-O-DMT-dU) is a competitive inhibitor of E. coli dUTP nucleotidohydrolase (dUTPase), with the Ki higher than 1000 μM. 5'-O- (4,4'-Dimethoxytrityl) -2'-deoxyuridine can be used in machine-assisted DNA synthesis by synthesizing nucleosidic phosphoramidite blocks[1][2].

Product Specifications

CAS Number

[23669-79-6]

Product Name Alternative

5'-O-DMT-dU

UNSPSC

12352200

Hazard Statement

H302, H315, H319, H335

Target

DNA/RNA Synthesis

Type

Biochemical Assay Reagents

Related Pathways

Cell Cycle/DNA Damage

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/5-o-4-4-dimethoxytrityl-2-deoxyuridine.html

Concentration

10mM

Purity

98.20

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

COC1=CC=C(C(C2=CC=C(OC)C=C2)(OC[C@@H]3[C@@H](O)C[C@@H](O3)N4C=CC(NC4=O)=O)C5=CC=CC=C5)C=C1

Molecular Formula

C30H30N2O7

Molecular Weight

530.57

Precautions

H302, H315, H319, H335

References & Citations

[1]Hidalgo-Zarco F, et, al. Kinetic properties and inhibition of the dimeric dUTPase-dUDPase from Leishmania major. Protein Sci. 2001 Jul;10 (7) :1426-33.|[2]Hovinen J, et, al. Versatile strategy for oligonucleotide derivatization. Introduction of lanthanide (III) chelates to oligonucleotides. Org Lett. 2001 Aug 9;3 (16) :2473-6.