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Rp-cAMPS (sodium salt)

Product Specifications

UNSPSC Description

Rp-cAMPS sodium salt, a cAMP analog, is a potent, competitive cAMP-induced activation of cAMP-dependent PKA I and II (Kis of 12.5 µM and 4.5 µM, respectively) antagonist. Rp-cAMPS sodium salt is resistant to hydrolysis by phosphodiesterases[1][2][3][4][5][6].

Target Antigen

PKA

Type

Reference compound

Related Pathways

Stem Cell/Wnt;TGF-beta/Smad

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/rp-camps-sodium-salt.html

Purity

99.69

Solubility

DMSO : 25 mg/mL (ultrasonic;warming;heat to 60°C)|H2O : 250 mg/mL (ultrasonic)

Smiles

O[C@H]1[C@@H](O[C@@]2([H])[C@@]1([H])O[P@@](OC2)([S-])=O)N3C4=C(C(N)=NC=N4)N=C3.[Na+]

Molecular Weight

367.25

References & Citations

[1]Rothermel JD, et al. A mechanistic and kinetic analysis of the interactions of the diastereoisomers of adenosine 3',5'-(cyclic)phosphorothioate with purified cyclic AMP-dependent protein kinase. Biochem J. 1988 May 1;251(3):757-62.|[2]Fu Y, et al. PKA and ERK, but not PKC, in the amygdala contribute to pain-related synaptic plasticity and behavior. Mol Pain. 2008 Jul 16;4:26.|[3]Kuriyama S, et al. Isoproterenol inhibits rod outer segment phagocytosis by both cAMP-dependent and independent pathways. Invest Ophthalmol Vis Sci. 1995 Mar;36(3):730-6.|[4]Dostmann WR, et al. Probing the cyclic nucleotide binding sites of cAMP-dependent protein kinases I and II with analogs of adenosine 3',5'-cyclic phosphorothioates. J Biol Chem. 1990 Jun 25;265(18):10484-91.|[5]Van Haastert PJ, et al. Competitive cAMP antagonists for cAMP-receptor proteins. J Biol Chem. 1984 Aug 25;259(16):10020-4.|[6]R J de Wit, et al. Inhibitory action of certain cyclophosphate derivatives of cAMP on cAMP-dependent protein kinases. Eur J Biochem. 1984 Jul 16;142(2):255-60.Cell Commun Signal. 2024 Jun 3;22(1):307.|Research Square Preprint. 2024 Apr 9.|Theranostics. 2021 Mar 24;11(12):5650-5674.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, sealed storage, away from moisture and light)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-100530D/Rp-cAMPS-sodium-salt-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-100530D/Rp-cAMPS-sodium-salt-SDS-MedChemExpress.pdf

Clinical Information

No Development Reported

CAS Number

142439-94-9

Available Sizes

Curated Selection

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