Spiradoline (mesylate)

Spiradoline mesylate (U-62066 mesylate), an arylacetamide, is a selective kappa opioid receptor (KOR) agonist with a Ki of 8.6 nM in guinea pig. The Ki values of Spiradoline mesylate for μ and δ receptors are 252 nM and 9400 nM, respectively. Spiradoline mesylate has potent diuretic, analgesic, antiarrythmic, antitussive, neuroprotective properties and easily penetrates the blood-brain barrier[1][2].

Product Specifications

CAS Number

[87173-97-5]

Product Name Alternative

U-62066 (mesylate)

UNSPSC

12352005

Target

Opioid Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/spiradoline-mesylate.html

Purity

99.95

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

ClC1=C(C=CC(CC(N([C@H]2CC[C@@]3(C[C@@H]2N4CCCC4)OCCC3)C)=O)=C1)Cl.CS(O)(=O)=O

Molecular Formula

C23H34Cl2N2O5S

Molecular Weight

521.50

References & Citations

[1]Elena I Varlinskaya, et al. Stress alters social behavior and sensitivity to pharmacological activation of kappa opioid receptors in an age-specific manner in Sprague Dawley rats. Neurobiol Stress. 2018 Sep 11;9:124-132.|[2]M-L G Wadenberg. A review of the properties of spiradoline: a potent and selective kappa-opioid receptor agonist. CNS Drug Rev. Summer 2003;9 (2) :187-98.