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Irinotecan (hydrochloride) (Standard)

Irinotecan (hydrochloride) (Standard) is the analytical standard of Irinotecan (hydrochloride) . This product is intended for research and analytical applications. Irinotecan hydrochloride ((+) -Irinotecan hydrochloride) is a topoisomerase I inhibitor mainly used to treat colon cancer and rectal cancer[1].

Product Specifications

CAS Number

100286-90-6

Product Name Alternative

(+) -Irinotecan (hydrochloride) (Standard) ; CPT-11 (hydrochloride) (Standard) ; VAL-413 (Standard)

UNSPSC

12352005

Target

Autophagy; Reference Standards; Topoisomerase

Type

Reference compound

Related Pathways

Autophagy; Cell Cycle/DNA Damage; Others

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/irinotecan-hydrochloride-standard.html

Smiles

O=C(N1CCC(N2CCCCC2)CC1)OC3=CC=C4N=C5C(CN6C(C(COC([C@@]7(CC)O)=O)=C7C=C65)=O)=C(CC)C4=C3.[H]Cl

Molecular Formula

C33H39ClN4O6

Molecular Weight

623.14

References & Citations

[1]Morales C, et al. Antitumoral effect of irinotecan (CPT-11) on an experimental model of malignant neuroectodermal tumor. J Neurooncol. 2002 Feb;56 (3) :219-26.|[2]Pavillard V, et al. Determinants of the cytotoxicity of irinotecan in two human colorectal tumor cell lines. Cancer Chemother Pharmacol. 2002 Apr;49 (4) :329-35. Epub 2002 Jan 30.|[3]Allegrini G, et al. Thrombospondin-1 plus irinotecan: a novel antiangiogenic-chemotherapeutic combination that inhibits the growth of advanced human colon tumor xenografts in mice. Cancer Chemother Pharmacol. 2004 Mar;53 (3) :261-6. Epub 2003 Dec 5.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

Available Sizes

Frequently Asked Questions

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