Temgicoluril

Temgicoluril (Tetramethylglycoluril) is an orally active antianxiety and antidepressant. Temgicoluril acts on GABA receptors to enhance GABA neurotransmission[1][2].

Product Specifications

CAS Number

[10095-06-4]

Product Name Alternative

Tetramethylglycoluril

UNSPSC

12352005

Hazard Statement

H302

Target

GABA Receptor

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/temgicoluril.html

Concentration

10mM

Purity

98.03

Solubility

DMSO : 125 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)

Smiles

O=C1N(C2N(C)C(N(C2N1C)C)=O)C

Molecular Formula

C8H14N4O2

Molecular Weight

198.22

Precautions

H302

References & Citations

[1]Val'dman AV, Zaikonnikova IV, Kozlovskaia MM, Zimakova IE. Izuchenie osobennosteĭ spektra psikhotropnogo deĭstviia mebikara [Characteristics of the psychotropic spectrum of action of mebicar]. Biull Eksp Biol Med. 1980 May;89 (5) :568-70. Russian.|[2]Kim CY, et al. Preventive Effect of Mebicar and Ginsenoside Rg1 on Neurobehavioral and Immunological Disruptions Caused by Intermittent Unpredictable Stress in Mice. Neuroimmunomodulation. 2018;25 (1) :49-58.