PARP1-IN-5 (dihydrochloride)

PARP1-IN-5 dihydrochloride is a low toxicity, orally active, potent and selective PARP-1 inhibitor (IC50 =14.7 nM) . PARP1-IN-5 dihydrochloride can be used for the research of cancer[1].

Product Specifications

CAS Number

[2823308-89-8]

UNSPSC

12352005

Target

PARP

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/parp1-in-5-dihydrochloride.html

Purity

97.56

Solubility

DMSO : 125 mg/mL (ultrasonic) |H2O : 1 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C1C=C(OC2=C1C(O)=CC(O)=C2CN3CCN(CC3)CC4=CC=CS4)C5=CC=C(C=C5)O.[H]Cl.[H]Cl

Molecular Formula

C25H26Cl2N2O5S

Molecular Weight

537.46

References & Citations

[1]Long H, et al. Discovery of Novel Apigenin-Piperazine Hybrids as Potent and Selective Poly (ADP-Ribose) Polymerase-1 (PARP-1) Inhibitors for the Treatment of Cancer. J Med Chem. 2021;64 (16) :12089-12108.