BAY-598

BAY-598, a chemical probe, is selective small molecule inhibitor of SMYD2 with an IC50 of 27 nM[1][2].

Product Specifications

CAS Number

[1906919-67-2]

UNSPSC

12352005

Hazard Statement

H302

Target

Histone Methyltransferase

Type

Reference compound

Related Pathways

Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/BAY-598.html

Purity

99.33

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

ClC1=C(Cl)C=CC(C2=NN(/C(NC#N)=N/C3=CC=CC(OC(F)F)=C3)C[C@@H]2N(C(CO)=O)CC)=C1

Molecular Formula

C22H20Cl2F2N6O3

Molecular Weight

525.34

Precautions

H302

References & Citations

[1]Reynoird N, et al. Coordination of stress signals by the lysine methyltransferase SMYD2 promotes pancreaticcancer. Genes Dev. 2016 Apr 1;30 (7) :772-85.|[2]Eggert E, et al. Discovery and Characterization of a Highly Potent and Selective Aminopyrazoline-Based in Vivo Probe (BAY-598) for the Protein Lysine Methyltransferase SMYD2. J Med Chem. 2016 May 26;59 (10) :4578-600.