BAY-598
BAY-598, a chemical probe, is selective small molecule inhibitor of SMYD2 with an IC50 of 27 nM[1][2].
Product Specifications
CAS Number
1906919-67-2
UNSPSC
12352005
Hazard Statement
H302
Target
Histone Methyltransferase
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/BAY-598.html
Purity
99.33
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
ClC1=C(Cl)C=CC(C2=NN(/C(NC#N)=N/C3=CC=CC(OC(F)F)=C3)C[C@@H]2N(C(CO)=O)CC)=C1
Molecular Formula
C22H20Cl2F2N6O3
Molecular Weight
525.34
Precautions
H302
References & Citations
[1]Reynoird N, et al. Coordination of stress signals by the lysine methyltransferase SMYD2 promotes pancreaticcancer. Genes Dev. 2016 Apr 1;30 (7) :772-85.|[2]Eggert E, et al. Discovery and Characterization of a Highly Potent and Selective Aminopyrazoline-Based in Vivo Probe (BAY-598) for the Protein Lysine Methyltransferase SMYD2. J Med Chem. 2016 May 26;59 (10) :4578-600.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
SMYD2
Available Sizes
Frequently Asked Questions
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