KL001

KL001 is a first-in-class cryptochrome (CRY, a flavoproteins that are sensitive to blue light, and is involved in the circadian rhythms of plants and animals) stabilizer which specifically interacts with CRY1 and CRY2. KL001 prevents ubiquitin-dependent degradation of CRY, resulting in lengthening of the circadian period. KL001 has the potential to control fasting hormone-induced gluconeogenesis[1][2][3].

Product Specifications

CAS Number

[309928-48-1]

UNSPSC

12352005

Hazard Statement

H302

Target

Cryptochrome

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/kl001.html

Purity

99.68

Solubility

DMSO : 5 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

CS(=O)(N(CC(O)CN1C2=C(C3=C1C=CC=C3)C=CC=C2)CC4=CC=CO4)=O

Molecular Formula

C21H22N2O4S

Molecular Weight

398.48

Precautions

H302

References & Citations

[1]Hirota T, et, al. Identification of small molecule activators of cryptochrome. Science. 2012 Aug 31;337 (6098) :1094-7.|[2]Kelleher FC, et, al. Circadian molecular clocks and cancer. Cancer Lett. 2014 Jan 1;342 (1) :9-18.|[3]Nangle S, et, al. Crystal structure of mammalian cryptochrome in complex with a small molecule competitor of its ubiquitin ligase. Cell Res. 2013 Dec;23 (12) :1417-9.