Boc-Val-Ala-PAB

Boc-Val-Ala-PAB is a cathepsin cleavable ADC linker that is used for making antibody-drug conjugate (ADCs) [1][2].

Product Specifications

CAS Number

[1884577-99-4]

UNSPSC

12352005

Hazard Statement

H315, H319

Target

ADC Linker

Type

Reference compound

Related Pathways

Antibody-drug Conjugate/ADC Related

Applications

Cancer-programmed cell death

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/boc-val-ala-pab.html

Purity

99.98

Solubility

10 mM in DMSO

Smiles

O=C(N[C@@H](C)C(NC(C=C1)=CC=C1CO)=O)[C@H](C(C)C)NC(OC(C)(C)C)=O

Molecular Formula

C20H31N3O5

Molecular Weight

393.48

Precautions

H315, H319

References & Citations

[1]HP Wilson, et al. Pyrrolobenzodiazepines and conjugates thereof: World Intellectual Property Organization, WO2016037644. 2016-03-17. |[2]HP Wilson, et al. Preparation of pyrrolobenzodiazepine dimers and their conjugates with cell binding agents, especially pyrrolobenzodiazepine dimer drug linker antibody conjugates and their use for treating proliferative diseases, particularly cancer: World Intellectual Property Organization, WO2016038383. 2016-03-17