INF 195
Product Specifications
UNSPSC Description
INF 195 is an NLRP3 inhibitor. INF 195 can inhibit NLRP3 driven macrophage pyroptosis and IL-1β release, with an EC50 value of 0.15 μM. INF 195 can reduce the infarct size of isolated mouse hearts at low doses, effectively preventing myocardial ischemia/reperfusion injury[1].
Target Antigen
Interleukin Related; NOD-like Receptor (NLR); Pyroptosis
Type
Reference compound
Related Pathways
Apoptosis;Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/inf-195.html
Solubility
DMSO : 200 mg/mL (ultrasonic)
Smiles
O=C(C1CN(C(CCC2=CC=CC=C2Cl)=O)CCC1)OCC
Molecular Weight
323.81
References & Citations
[1]Gastaldi S, et al. Novel NLRP3 inhibitor INF195: Low doses provide effective protection against myocardial ischemia/reperfusion injury. Vascul Pharmacol. 2024 Jun 17;156:107397.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-164304/INF-195-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-164304/INF-195-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1211379-56-4
Available Sizes
Curated Selection
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