INF 195
INF 195 is an NLRP3 inhibitor. INF 195 can inhibit NLRP3 driven macrophage pyroptosis and IL-1β release, with an EC50 value of 0.15 μM. INF 195 can reduce the infarct size of isolated mouse hearts at low doses, effectively preventing myocardial ischemia/reperfusion injury[1].
Product Specifications
CAS Number
[1211379-56-4]
UNSPSC
12352005
Target
Interleukin Related; NOD-like Receptor (NLR) ; Pyroptosis
Type
Reference compound
Related Pathways
Apoptosis; Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/inf-195.html
Purity
99.58
Solubility
DMSO : 200 mg/mL (ultrasonic)
Smiles
O=C(C1CN(C(CCC2=CC=CC=C2Cl)=O)CCC1)OCC
Molecular Formula
C17H22ClNO3
Molecular Weight
323.81
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IL-1; NLRP3
Available Sizes
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