PF-05241328
PF-05241328 is a potent and selective inhibitor of human Nav1.7 voltage-dependent sodium channels (Nav1.7), with an IC50 of 31 nM.
Product Specifications
CAS Number
[1387633-03-5]
UNSPSC
12352005
Target
Sodium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/PF-05241328.html
Purity
98.08
Solubility
DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(C1=CC2=C(N(C3=CC(Cl)=C(OCC(C)C)N=C3)N=C2C)C=C1)NS(=O)(C)=O
Molecular Formula
C19H21ClN4O4S
Molecular Weight
436.91
References & Citations
[1]Jones HM, et al. Clinical Micro-Dose Studies to Explore the Human Pharmacokinetics of Four Selective Inhibitors of Human Nav1.7 Voltage-Dependent Sodium Channels. Clin Pharmacokinet. 2016 Jul;55 (7) :875-887.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
Nav1.7
Available Sizes
More Discoveries
Explore Other Products
Browse additional items from our catalog
036889-AP 200 µL
IFNA5, CT (IFNA5, Interferon alpha-5, Interferon alpha-61, Interferon alpha-G) (AP) discontinued
Sign In for Pricing
View Details ![tert-Butyl 6-(Benzyloxycarbonylamino)-2,3-Dihydro-1H-Imidazo{1,2-b]pyrazole-1-carboxylate](https://cdn.genprice.uk/genprice/uk/genprice4.webp)
TRC-B812956-100MG 100 mg
tert-Butyl 6-(Benzyloxycarbonylamino)-2,3-Dihydro-1H-Imidazo{1,2-b]pyrazole-1-carboxylate
Sign In for Pricing
View Details 
OR1062344-01 100 mg
2-[10- ([1,1'-Biphenyl]-4-yl) anthracen-9-yl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
Sign In for Pricing
View Details