NLRP3-IN-38
NLRP3-IN-38 (Compound 18) is an inhibitor for NOD-like receptor protein 3 (NLRP3), that inhibits NLRP3 inflammasome activation with an EC50 of 23 nM[1].
Product Specifications
CAS Number
[3033054-46-2]
UNSPSC
12352005
Target
NOD-like Receptor (NLR)
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/nlrp3-in-38.html
Solubility
10 mM in DMSO
Smiles
C[C@H]1CN(C[C@H]([C@@H]1O)C)C2=C3C=NC=CC3=C(N=N2)C4=CC=C(C=C4O)C(F)(F)F
Molecular Formula
C21H21F3N4O2
Molecular Weight
418.41
References & Citations
[1]Donna A. A. W. HAYES, et al., Phthalazine derivatives useful as inhibitors of nod-like receptor protein 3. WO2024064245A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
NLRP3
Curated Selection
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