NLRP3-IN-38
NLRP3-IN-38 (Compound 18) is an inhibitor for NOD-like receptor protein 3 (NLRP3), that inhibits NLRP3 inflammasome activation with an EC50 of 23 nM[1].
Product Specifications
CAS Number
[3033054-46-2]
UNSPSC
12352005
Target
NOD-like Receptor (NLR)
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/nlrp3-in-38.html
Solubility
10 mM in DMSO
Smiles
C[C@H]1CN(C[C@H]([C@@H]1O)C)C2=C3C=NC=CC3=C(N=N2)C4=CC=C(C=C4O)C(F)(F)F
Molecular Formula
C21H21F3N4O2
Molecular Weight
418.41
References & Citations
[1]Donna A. A. W. HAYES, et al., Phthalazine derivatives useful as inhibitors of nod-like receptor protein 3. WO2024064245A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
NLRP3
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
130413 100 µg
NALP2 (NACHT, LRR and PYD Domains-containing Protein 2, Nucleotide-binding site Protein 1, PYRIN Domain and NACHT Domain-containing Protein 1, PYRIN-containing APAF1-like Protein 2, NLRP2, NBS1, PAN1, PYPAF2, CLR19.9, FLJ20510)
Ask
View Details