NLRP3-IN-38

NLRP3-IN-38 (Compound 18) is an inhibitor for NOD-like receptor protein 3 (NLRP3), that inhibits NLRP3 inflammasome activation with an EC50 of 23 nM[1].

Product Specifications

CAS Number

[3033054-46-2]

UNSPSC

12352005

Target

NOD-like Receptor (NLR)

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/nlrp3-in-38.html

Solubility

10 mM in DMSO

Smiles

C[C@H]1CN(C[C@H]([C@@H]1O)C)C2=C3C=NC=CC3=C(N=N2)C4=CC=C(C=C4O)C(F)(F)F

Molecular Formula

C21H21F3N4O2

Molecular Weight

418.41

References & Citations

[1]Donna A. A. W. HAYES, et al., Phthalazine derivatives useful as inhibitors of nod-like receptor protein 3. WO2024064245A1.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

NLRP3

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