ACBI1
ACBI1 is a potent and cooperative SMARCA2, SMARCA4 and PBRM1 degrader with DC50s of 6, 11 and 32 nM, respectively. ACBI1 is a PROTAC degrader. ACBI1 shows anti-proliferative activity. ACBI1 induces apoptosis[1].
Product Specifications
CAS Number
2375564-55-7
UNSPSC
12352005
Hazard Statement
H302, H312, H332
Target
Apoptosis; PROTACs; SWI/SNF Complex
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/acbi1.html
Purity
99.92
Solubility
DMSO : ≥ 100 mg/mL
Smiles
CC(N=CS1)=C1C2=CC=C(CNC([C@@H]3C[C@@H](O)CN3C([C@H](C(C)(C)C)NC(C4(CC4)F)=O)=O)=O)C(OCCOC5=CC=C(CN6CCN(C7=CC(C8=C(O)C=CC=C8)=NN=C7N)CC6)C=C5)=C2
Molecular Formula
C49H58FN9O7S
Molecular Weight
936.10
Precautions
H302, H312, H332
References & Citations
[1]Farnaby W, et al. BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design. Nat Chem Biol. 2019 Jul;15 (7) :672-680.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Protein Polybromo-1; SMARCA2; SMARCA4; von Hippel-Lindau (VHL)
Available Sizes
Frequently Asked Questions
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