Zaragozic acid D
Zaragozic acid D is a squalene synthase inhibitor. Zaragozic acid D also is a farnesyl-protein transferase (FPTase) inhibitor with an IC50 value of 100 nM for bovine FPTase[1][2].
Product Specifications
CAS Number
[155179-14-9]
UNSPSC
12352005
Target
Farnesyl Transferase
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/zaragozic-acid-d.html
Smiles
OC([C@]12[C@@H]([C@H]([C@](O1)(O[C@@H]([C@@]2(O)C(O)=O)C(O)=O)CCCC(OC(C)=O)C(C)C/C=C/C3=CC=CC=C3)O)OC(CCCCCCC)=O)=O
Molecular Formula
C34H46O14
Molecular Weight
678.72
References & Citations
[1]Leeyuan Huang, et al. New fungal metabolites as potential antihypercholesterolemics and anticancer agents. Canadian Journal of Botany, 1995, 73 (S1) : 898-906.|[2]Dufresne C, et al. Zaragozic acids D and D2: potent inhibitors of squalene synthase and of Ras farnesyl-protein transferase. J Nat Prod. 1993 Nov;56 (11) :1923-9.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
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