Zaragozic acid D

Zaragozic acid D is a squalene synthase inhibitor. Zaragozic acid D also is a farnesyl-protein transferase (FPTase) inhibitor with an IC50 value of 100 nM for bovine FPTase[1][2].

Product Specifications

CAS Number

[155179-14-9]

UNSPSC

12352005

Target

Farnesyl Transferase

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/zaragozic-acid-d.html

Smiles

OC([C@]12[C@@H]([C@H]([C@](O1)(O[C@@H]([C@@]2(O)C(O)=O)C(O)=O)CCCC(OC(C)=O)C(C)C/C=C/C3=CC=CC=C3)O)OC(CCCCCCC)=O)=O

Molecular Formula

C34H46O14

Molecular Weight

678.72

References & Citations

[1]Leeyuan Huang, et al. New fungal metabolites as potential antihypercholesterolemics and anticancer agents. Canadian Journal of Botany, 1995, 73 (S1) : 898-906.|[2]Dufresne C, et al. Zaragozic acids D and D2: potent inhibitors of squalene synthase and of Ras farnesyl-protein transferase. J Nat Prod. 1993 Nov;56 (11) :1923-9.