GS-621763
GS-621763 is an orally available precursor to GS-441524 that exhibits anti-SARS-CoV-2 viral activity in mice. GS-621763 reduces viral load to undetectable levels in ferrets infected with SARS-CoV-2[1][2].
Product Specifications
CAS Number
2647442-13-3
UNSPSC
12352005
Target
SARS-CoV
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/gs-621763.html
Purity
99.72
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
N#C[C@]1(C2=CC=C3N2N=CN=C3N)[C@@H]([C@@H]([C@H](O1)COC(C(C)C)=O)OC(C(C)C)=O)OC(C(C)C)=O
Molecular Formula
C24H31N5O7
Molecular Weight
501.53
References & Citations
[1]Schäfer A, et al. Therapeutic efficacy of an oral nucleoside analog of remdesivir against SARS-CoV-2 pathogenesis in mice. bioRxiv [Preprint]. 2021 Sep 17:2021.09.13.460111.|[2]Cox RM, et al. Oral prodrug of remdesivir parent GS-441524 is efficacious against SARS-CoV-2 in ferrets. Nat Commun. 2021 Nov 5;12 (1) :6415.|[3]Cox RM, et al. Oral prodrug of remdesivir parent GS-441524 is efficacious against SARS-CoV-2 in ferrets. Nat Commun. 2021 Nov 5;12 (1) :6415.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
LC422006 20 µg
GOLGA6 (GOLGA6A) (NM_001038640) Human Over-expression Lysate
Sign In for Pricing
View Details 
![AKT2 Mouse Monoclonal Antibody (HRP conjugated) [Clone ID: OTI4G1]](https://cdn.genprice.uk/products/937/6868c319994c49e6dc3eef5f/imageurl/ta500831bm.webp)
TA500831BM 100 µL
AKT2 Mouse Monoclonal Antibody (HRP conjugated) [Clone ID: OTI4G1]
Sign In for Pricing
View Details 